A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two dosesArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administering boost caused coronavirus COVID-19 CP: Immunology Donor dose elicit elicited extended interval humoral Humoral response humoral responses individual Infection long interval mRNA vaccine observé omicron regimen robust SARS-CoV-2 SARS-CoV-2 BNT162b2 second dose significantly spike glycoproteins third mRNA vaccine dose vaccinated individuals variant variants of concern variants of concern. VoC VOCs [DOI] 10.1016/j.celrep.2022.111554 PMC 바로가기
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization우려되는 SARS-CoV-2 변이체: 스파이크 단백질 돌연변이 분석 및 광범위한 중화를 위한 에피토프Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antibody neutralization antigenic binding circulating variants Comparative analysis consequence convalescent sera cryo-EM Effect ENhance epitope exhibit functional Gamma highlight identify mutated Mutation N-terminal domain neutralization neutralize NTD omicron RBD SARS-CoV-2 spike SARS-CoV-2 spike mutations SARS-CoV-2 variant SARS-CoV-2 variants shown spike glycoprotein spike glycoproteins Spike protein structural rearrangements unique variant variant spike [DOI] 10.1038/s41467-022-32262-8 PMC 바로가기 [Article Type] Article
Repurposing of anti-lung cancer drugs as multi-target inhibitors of SARS-CoV-2 proteins: An insight from molecular docking and MD-simulation studySARS-CoV-2 단백질의 다중 표적 억제제로서 항폐암 약물의 용도 변경: 분자 도킹 및 MD 시뮬레이션 연구로부터의 통찰력Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis binding affinity binding energy Cancer Capmatinib conformational change COVID-19 drug Dynamics evaluate Glycoproteins highest binding affinity inhibitors of SARS-CoV-2 molecular docking molecular docking studies Molecular docking study molecular dynamics Molecular dynamics simulation MPro pharmacokinetic PLPro Protein repurposing Research RMSD RMSF SARS-CoV-2 selected spike spike glycoprotein spike glycoproteins Spike protein spike protein. therapeutic therapeutic agent [DOI] 10.1016/j.micpath.2022.105615 PMC 바로가기 [Article Type] Article
MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine vaccine. Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
Plasmonic Approaches for the Detection of SARS-CoV-2 Viral ParticlesSARS-CoV-2 바이러스 입자 검출을 위한 플라즈몬 접근법Review Published on 2022-07-212022-09-11 Journal: Biosensors [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody treatment applicability approach Care caused contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detection diagnostic diagnostic testing diagnostics focus genetic material highlight Highlights Infection infectivity testing neutralizing antibody non-infected nucleocapsid outbreak pandemic Particle Patient platform POCT point-of-care point-of-care testing Protein provided respiratory reverse transcription PCR RT-PCR S1 protein SARS-CoV-2 SARS-CoV-2 viral particle SARS-CoV-2 viral particles SARSC-CoV-2 severe acute respiratory syndrome Coronavirus spike glycoprotein spike glycoproteins Spike protein SPR structural proteins surface plasmon surface plasmon resonance surface plasmonic resonance (SPR). the S1 protein therapeutic Treatment Vaccine Viral viral particle Viral particles Viral protein virus while [DOI] 10.3390/bios12070548 PMC 바로가기 [Article Type] Review
Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen16주 간격 BNT162b2 요법에서 강력한 백신 반응성과 B 및 T 세포 면역의 시간적 연관성Article Published on 2022-06-282022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Administered AIM assay Analysis association associations B cell B cell response B cells BNT162b2 BNT162b2 mRNA CD4 CD4 T cell CD4 T cell help CD8 CD8 T cell cellular Clustering cohorts coronavirus COVID-19 CP: Immunology donors dose Efficacy elicit feature first dose functional humoral Humoral response humoral responses immune immune memory Immunity immunological Immunological memory longer interval magnitude memory T mRNA mRNA vaccine of BNT162b2 participant phenotypic raise recall regimen response reveal robust SARS-CoV-2 second dose single-cell spacing spike spike glycoproteins T cell T cell response T helper Temporal Vaccine vaccine regimen. while [DOI] 10.1016/j.celrep.2022.111013 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between dosesComparative Study Published on 2022-03-012023-07-08 Journal: Cell Reports [Category] COVID19(2023년), [키워드] coronavirus COVID-19 delayed mRNA vaccine regimen humoral responses neutralization omicron SARS-CoV-2 spike glycoproteins variants of concern. [DOI] 10.1016/j.celrep.2022.110429 PMC 바로가기 [Article Type] Comparative Study
Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 SpikesCommunication Published on 2022-01-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ACE2 ACE2 binding ACE2 receptor antigenicity B.1.1.7 B.1.351 B.1.617.2 B.1.621 Beta coronavirus COVID-19 COVID-19 pandemic Critical Delta E484K Gamma Interaction L452R mRNA vaccines Mutation N501Y neutralization ability neutralized P.1 parameter Particle plasma RBD SARS-CoV-2 SARS-CoV-2 variant spike spike glycoproteins temperature the receptor-binding domain the Spike vaccinated individual variant variants variants of concern variants of interest variants under monitoring [DOI] 10.3390/v14010144 PMC 바로가기 [Article Type] Communication
Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses16주 간격으로 BNT162b2 mRNA 백신 접종 후 SARS-CoV-2 스파이크에 대한 강력한 체액성 면역 반응Article Published on 2022-01-122022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] ADCC Administered analyzed BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cohort coronavirus COVID-19 D614G delayed mRNA vaccine regimen dose doses Efficacy elicited greater health authorities humoral humoral immune response Humoral response humoral responses IMPROVE include individual infected individual infected individuals mRNA vaccine naïve individuals naïve vaccinees neutralization public health authority question raising receiving regimen response robust SARS-CoV-2 second dose significantly significantly increased spike spike glycoproteins Strong vaccine administration vaccine dose vaccine doses vaccinees variant variants variants of concern variants of interest variants of interest. while [DOI] 10.1016/j.chom.2021.12.004 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Expression at the Surface of Infected Primary Human Airway Epithelial CellsCommunication Published on 2021-12-212022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] airway epithelial cell anti-S2 antibody antibody-dependent cellular cytotoxicity (ADCC) antigenicity assays authentic virus convalescent convalescent plasma correlated COVID-19 evaluate expressed expressing expression form full-length glycoprotein Human human primary airway epithelial cells Humoral response infected cell intrinsic mRNA vaccine neutralization nucleocapsid physiological plasma primary cell primary cells RBD Receptor binding domain robust SARS-CoV-2 SARS-CoV-2 D614G Serological assay serological assays spike spike glycoproteins staining surface the SARS-CoV-2 the Spike uninfected cells vaccinated individual variants virus were infected [DOI] 10.3390/v14010005 PMC 바로가기 [Article Type] Communication